Table 4.
Weight and blood gas analysis in 13–16- and 18–21-day-old NBCe1 WT and KO mice
| NBCe1+/+ (14–15 days) | NBCe1+/+ (18–20 days) | NBCe1−/− (12–14 days) | NBCe1−/− (18–20 days) | |
|---|---|---|---|---|
| Body weight (g) | 8.85 ± 0.66 | 8.92 ± 0.17 | 6.36 ± 0.56* | 4.90 ± 0.29****§ |
| pH | 7.42 ± 0.01 | 7.41 ± 0.01 | 7.11 ± 0.03**** | 6.71 ± 0.06****§§§§ |
| pCO2 (mmHg) | 39.8 ± 4.7 | 34.5 ± 1.5 | 25.8 ± 3.6* | 19.9 ± 3.1*** |
| pO2 (mmHg) | 267.4 ± 15.6 | 265.1 ± 10.9 | 254.1 ± 23.2 | 287.8 ± 6.9 |
| sO2 (%) | 100 ± 0.0 | 99.5 ± 0.1 | 99.7 ± 0.1 | 99.3 ± 0.2 |
| HCO3 − (mmol/L) | 25.1 ± 2.7 | 21.2 ± 0.9 | 7.8 ± 1.2**** | 2.5 ± 0.5****§§§ |
| ABE (mmol/L) | 1.4 ± 2.3 | −2.3 ± 1.0 | −21.6 ± 1.7**** | |
| SBE (mmol/L) | 1.2 ± 2.7 | −2.8 ± 1.1 | −19.9 ± 1.5**** | −27.6 ± 1.2****§§§ |
| SBC (mmol/L) | 25.8 ± 2.1 | 22.5 ± 0.8 | 9.9 ± 0.9**** |
*Compared between WT and KO group, §compared between 12–14 and 18–20 days in KO group, 14–16 days n = 7–10, 18–20 days n = 13–15. There were no ABE and SBC values in 18–20-days KO group because of serious metabolic acidosis. The high pO2 is due to the isoflurane/O2 mixture used for narcosis prior to taking blood
****§§§§ p < 0.0001