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Presence of ACTH in the normal human adrenal. ACTH immunoreactivity is exclusively located in some chromaffin cells (high panel), identified as chromogranin A (CGA) immunoreactive cells (low panel), in the medulla. ACTH was detected by using antibodies against the N-terminal region of the peptide. ZF, zona fasciculata; ZR, zona reticularis. Illustration of the data published in Ref. (9).
