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. 2016 Jul 20;7:98. doi: 10.3389/fendo.2016.00098

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Copyright © 2016 Lefebvre, Thomas, Duparc, Bertherat and Louiset.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intraadrenal ACTH regulation of cortisol secretion in bilateral macronodular adrenal hyperplasia (BMAH). (A,B) Consecutive sections of a BMAH tissue labeled with ACTH and MC2R antibodies. (A) Heterogeneous distribution of ACTH-producing cell clusters in BMAH. (B) The ACTH receptor MC2R is highly expressed in ACTH-producing cells (arrows) and in their vicinity. (C) ACTH sensitivity of BMAH tissues. Application of exogenous ACTH stimulated cortisol secretion by perifused BMAH explants. (D) Corticostatin, a MC2R antagonist, inhibited in vitro the cortisol response of cultured BMAH cells to ACTH. Illustration of the data published in Ref. (9).