Table 4. Daily fluid balance prior to CRRT for 28-day mortality in critically ill patients.

Daily fluid balance, L	HR [95% CI]	P value
Univariate	1.11 [1.02, 1.21]	0.014
Multivariate model 1*	1.12 [1.03, 1.22]	0.009
Multivariate model 2†	1.14 [1.04, 1.25]	0.007
Multivariate model 3‡	1.14 [1.03, 1.26]	0.012

CI, confidence interval; CRRT, continuous renal replacement therapy; HR, hazard ratio; ICU, intensive care unit; SOFA, sequential organ failure assessment.

^*Model 1 was adjusted by age and sex; ^†Model 2 was adjusted by age, sex and the total SOFA score at ICU admission; ^‡Model 3 was adjusted by age, sex, the total SOFA score at ICU admission and causes of AKI.