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. 2016 Jul 20;3(3):ENEURO.0138-16.2016. doi: 10.1523/ENEURO.0138-16.2016

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Copyright © 2016 Okamoto et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Modulation of IRs by 8-Br-cGMP in small and large MNs in the dl-TMN. Aa, Ab, Sample traces of responses to depolarizing and hyperpolarizing current pulses obtained before application (Aa) and during application (Ab) of 8-Br-cGMP in a small MN. Ac, The I–V relationships obtained before and during application of 8-Br-cGMP in a small MN. The I–V relationships measured at the peak sag potentials are almost linear (blue and red circles), while those measured just before the offset of current pulses are inwardly rectifying (blue and red crosses). Ba, Bb, Sample traces of responses to depolarizing and hyperpolarizing current pulses obtained before application (Ba) and during application (Bb) of 8-Br-cGMP in a large MN. Bc. The I–V relationships obtained before and during the application of 8-Br-cGMP in a large MN. C, The relationship between IRs of MNs and changes in IRs by 8-Br-cGMP (n = 14). D, EPSPs evoked by stimulation just dorsal to the TMN obtained before and during the application of 8-Br-cGMP in a large MN. E, The relationship between IRs and changes in EPSP amplitudes by 8-Br-cGMP (n = 13).