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. 2016 Jun 11;6(4):319–328. doi: 10.1016/j.apsb.2016.05.010

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© 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 10 — Daily serum biochemical parameters detected during safety evaluation of daptomycin-modified daptomycin-loaded liposomes. Alanine aminotransferase (A), aspartate aminotransferase (B), urea nitrogen (C), creatinine phosphokinase (D), creatinine (E) and uric acid (F) levels from normal mice were detected on days −1, 0, 1, 3 and 7. Mice from saline group, DPD-L[D] group and mPEG-L[D] group were administrated a dose of saline, daptomycin-modified daptomycin-loaded liposomes (mPEG-L[D] 25 mg/kg in a single i.v. dose), and PEGylated liposomal daptomycin (mPEG-L[D], 25 mg/kg in a single i.v. dose) on day 0, respectively. Each data point represents the mean±SD, n=6.