Skip to main content
. 2016 Jun 14;6(4):268–286. doi: 10.1016/j.apsb.2016.05.013

Figure 5.

Fig. 5

(A) The in vivo imaging of DiR-loaded NPs, AS1411 conjugated NPs (AsNPs), AsTNPs and TGN modified NPs (TNP) in the brain glioma-bearing nude mice at several time points with ex vivo imaging of the brain at 24 h. (B) Brain and glioma fluorescent intensity at 24 h. (C) The T/N ratio of the brains 24 h after treatment with different formulations. This study demonstrated that the dual targeting delivery strategy could not only increase the brain targeting efficiency but also improve the selectivity to brain tumor cells. Reprinted from Ref. 175 with permission of the copyright holder, Elsevier, Amsterdam.