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. 2016 Jul 20;6:29589. doi: 10.1038/srep29589

Figure 7. tBHQ lowers AngII-induced hypertension in wildtype (WT) mice, but not in hypertensive Akt−/− mice.

Figure 7

WT, Akt−/−, and eNOS−/− mice at the age of 8–12 weeks old were fed with normal diet containing tBHQ a ratio of 1% (w/w) for 2 weeks days prior to AngII infusion. Blood pressure (BP) was monitored by telemetry, as described in Materials and Methods. (A) Systolic BP and (B) diastolic BP in WT mice, (C) systolic BP and (D) diastolic BP in Akt−/− mice, and (E) systolic BP and (F) diastolic BP in eNOS−/− mice were analyzed. Quantitative results are expressed as mean ± SEM. N is 10–15 in each group. *P < 0.05 vs. Control WT or Akt−/− mice. #P < 0.05 vs. AngII mice.