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. 2016 Jul 20;6:29790. doi: 10.1038/srep29790

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Schematic diagram of the proposed model. PKCε is activated after treatment with ΨεRACK which enhances the activity of the transcriptional coactivator AMPK. AMPK upregulates the expression of Nampt which leads to increased Nampt localized to the mitochondria. Nampt enhances NAD⁺ levels which increases the lysine desuccinylase activity of SIRT5. SIRT5 desuccinylates multiple unknown targets in the mitochondria which lead to maintenance of mitochondrial complex activity and protection against an ischemic insult.