Table 3.
DAVID Functional Annotation Charts, 2-h Severe PE and 18-h Mild PE verses Vehicle
| a2-h Severe-PE verses Vehicle | 18-h Mild-PE verses Vehicle | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Category | Term | Ct | % | Dir | Fold | B&H | Ct | % | Dir | Fold | B&H |
| SP_PIR | acetylation | 78 | 14.03 | UP | 1.51 | 0.009 | |||||
| SP_PIR | activator | 7 | 7.29 | UP | 5.58 | 0.025 | |||||
| rno00970 | Aminoacyl-tRNA biosynthesis | 8 | 1.44 | UP | 5.56 | 0.017 | |||||
| rno00330 | Arginine and proline metabolism | 9 | 1.62 | UP | 4.72 | 0.015 | |||||
| rno05217 | Basal cell carcinoma | 10 | 1.11 | D | 4.28 | 0.016 | |||||
| IPR011700 | Basic leucine zipper | 4 | 4.17 | UP | 41.80 | 0.004 | |||||
| IPR004827 | Basic-leucine zipper (bZIP) transcription factor | 8 | 8.33 | UP | 28.54 | 0.000 | |||||
| SM00338 | BRLZ | 8 | 8.33 | UP | 20.66 | 0.000 | |||||
| IPR011616 | bZIP transcription factor, bZIP-1 | 4 | 4.17 | UP | 25.44 | 0.015 | |||||
| rno04062 | Chemokine signaling pathway | 20 | 3.60 | UP | 3.25 | 0.001 | |||||
| SP_PIR | chemotaxis | 4 | 4.17 | UP | 20.78 | 0.025 | 11 | 1.98 | UP | 10.30 | 0.000 |
| rno04610 | Complement and coagulation cascades | 10 | 1.80 | UP | 3.97 | 0.019 | |||||
| SP_PIR | cytokine | 9 | 9.38 | UP | 15.21 | 0.000 | 16 | 2.88 | UP | 4.88 | 0.000 |
| rno04060 | Cytokine-cytokine receptor interaction | 23 | 4.14 | UP | 3.25 | 0.000 | |||||
| SP_PIR | disulfide bond | 76 | 13.67 | UP | 1.43 | 0.044 | |||||
| SP_PIR | DNA binding | 6 | 6.25 | UP | 7.38 | 0.028 | |||||
| SP_PIR | dna-binding | 15 | 15.63 | UP | 3.75 | 0.002 | |||||
| UP_SEQ | DNA-binding region: Basic motif | 10 | 10.42 | UP | 15.44 | 0.000 | |||||
| UP_SEQ | domain: Leucine-zipper | 9 | 9.38 | UP | 19.96 | 0.000 | |||||
| rno00982 | Drug metabolism | 13 | 1.45 | D | 3.94 | 0.004 | |||||
| rno04512 | ECM-receptor interaction | 14 | 1.56 | D | 3.77 | 0.005 | |||||
| PIRSF001719 | fos transforming protein | 4 | 4.17 | UP | 109.20 | 0.000 | |||||
| IPR000837 | Fos transforming protein | 4 | 4.17 | UP | 83.59 | 0.001 | |||||
| rno00480 | Glutathione metabolism | 9 | 1.00 | D | 3.93 | 0.042 | |||||
| rno00340 | Histidine metabolism | 7 | 0.78 | D | 6.37 | 0.017 | |||||
| SP_PIR | inflammatory response | 4 | 4.17 | UP | 16.51 | 0.027 | 11 | 1.98 | UP | 8.18 | 0.000 |
| rno00980 | Metabolism of xenobiotics by cytochrome P450 | 13 | 1.45 | D | 4.73 | 0.002 | |||||
| rno04621 | NOD-like receptor signaling pathway | 5 | 5.21 | UP | 12.52 | 0.034 | 10 | 1.80 | UP | 4.49 | 0.016 |
| SP_PIR | nucleus | 22 | 22.92 | UP | 2.01 | 0.026 | |||||
| SP_PIR | oxidoreductase | 42 | 4.68 | D | 1.89 | 0.034 | |||||
| rno05020 | Prion diseases | 7 | 1.26 | UP | 5.56 | 0.028 | |||||
| SP_PIR | ribosome biogenesis | 7 | 1.26 | UP | 8.85 | 0.007 | |||||
| SM00199 | SCY | 5 | 5.21 | UP | 18.26 | 0.003 | 10 | 1.80 | UP | 8.76 | 0.000 |
| IPR001811 | Small chemokine, interleukin-8-like | 5 | 5.21 | UP | 25.22 | 0.002 | 10 | 1.80 | UP | 8.70 | 0.001 |
| SP_PIR | Transcription | 14 | 14.58 | UP | 3.23 | 0.009 | |||||
| SP_PIR | transcription regulation | 14 | 14.58 | UP | 3.48 | 0.006 | |||||
Functional annotations significantly over-represented in the lists of up-regulated and down-regulated genes during 2-h Severe PE and 18-h Mild PE. Annotations unique to both treatments are highlighted in bold Italics; unique annotations are in standard font. Keys are the same as in Table 1. aNo 2-h DOWN Annotations meet B&H < 0.05