Table 4.
Steroid/Sterol Biosynthesis Genes
| Symbol | Fold | Dir. | Gene Name |
|---|---|---|---|
| CH25H | 6.84 | UP | Cholesterol 25-hydroxylase |
| DHCR24 | 2.33 | UP | 24-dehydrocholesterol reductase |
| DHCR7 | 2.15 | UP | 7-dehydrocholesterol reductase |
| FDFT1 | 1.56a | UP | Farnesyl diphosphate farnesyl transferase 1 |
| FDPS | 1.89 | UP | Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) |
| HMGCR | 2.11a | UP | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| HMGCS1 | 3.74 | UP | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) |
| HSD17B12 | 3.03 | UP | Hydroxysteroid (17-beta) dehydrogenase 12 |
| HSD17B7 | 4.33 | UP | Hydroxysteroid (17-beta) dehydrogenase 7 |
| IDI1 | 8.61 | UP | Isopentenyl-diphosphate delta isomerase 1 |
| MVD | 3.34 | UP | Mevalonate (diphospho) decarboxylase |
| NSDHL | 1.84 | UP | NAD(P) dependent steroid dehydrogenase-like |
| SC4MOL | 1.9 | UP | Sterol-C4-methyl oxidase-like |
| SC5DL | 2.33a | UP | Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae) |
| SOAT1 | 2.59a | UP | Sterol O-acyltransferase 1 |
| SQLE | 3.26 | UP | Squalene epoxidase |
Steroid and sterol biosynthesis genes altered in the 18-h Severe PE treatment group. The three steroid/sterol annotations from Table 2 contained a total of 16 unique genes. All of the original DAVID downloads of PE-regulated annotations shown in Tables 1 and 2 and included lists of the genes within an annotation that were also altered by PE. These gene lists were very large and were not included in Tables 1, 2 and 3 to save space. The three annotations “SP_PIR Steroid biosynthesis”, “rno00100 Steroid biosynthesis” and “SP_PIR Sterol biosynthesis” contained 13, 9 and 11 genes, respectively. The 16 genes shown above represent the total unique genes. “Dir”, direction of fold-change. aAverage fold-change of 2 or more probesets for a single gene