Fig. 7.

Partial restoration of dystrophin expression in the TA muscle from mdx mice injected with AAV1-U7ex23. a RT-PCR analysis of Dmd exon 23 skipping in mdx mice injected with AAV1-U7ex23. b Quantification of Dmd exon 23 skipping in mdx mice injected with AAV1-U7ex23, c Dystrophin total mRNA level in mdx mice injected with AAV1-U7ex23. d Western blot analysis of dystrophin protein expression in mdx mice injected with AAV1-U7ex23, e Quantification of dystrophin protein expression in mdx mice injected with AAV1 U7ex23. U7-ex23 AAV1-U7ex23, Mdx mdx muscle injected with saline, Mdx + U7ex23 mdx muscle injected with AAV1-U7ex23, c significant difference with non-injected muscle (p < 0.05). n = 6–10 per group