Table 2.
Characteristics of HCV positive and negative individuals, BC-HTC, Canada, 1990-2013
| HCV + ve group | HCV -ve group | ||||
|---|---|---|---|---|---|
| M24 Seroa | >M24 Serob | Prevalent HCV | All Positives | All Negatives | |
| N = 3628 | N = 3436 | N = 48717 | N = 55781 | N = 988381 | |
| N (%) | N (%) | N (%) | N (%) | N (%) | |
| Age at baselinec | |||||
| < 15 | 17 (0.5) | 1 (0.0) | 420 (0.9) | 438 (0.8) | 20289 (2.1) |
| 15-24 | 962 (26.5) | 410 (11.9) | 2410 (5.0) | 3782 (6.8) | 145326 (14.7) |
| 25-34 | 1477 (40.7) | 1234 (35.9) | 9907 (20.3) | 12618 (22.6) | 259347 (26.2) |
| 35-44 | 827 (22.8) | 1106 (32.2) | 16534 (33.9) | 18467 (33.1) | 220626 (22.3) |
| 45-54 | 275 (7.6) | 522 (15.2) | 13068 (26.8) | 13865 (24.9) | 163134 (16.5) |
| ≥ 55 | 70 (1.9) | 163 (4.7) | 6378 (13.1) | 6611 (11.9) | 179659 (18.2) |
| Median [IQR] | 30 [24-37] | 35 [28-43] | 42 [34-49] | 41 [33-48] | 37 [28-50] |
| Age at 1st test | |||||
| < 15 | 100 (2.8) | 84 (2.4) | 421 (0.9) | 605 (1.1) | 25860 (2.6) |
| 15-24 | 1485 (40.9) | 1128 (32.8) | 2422 (5.0) | 5035 (9.0) | 189747 (19.2) |
| 25-34 | 1225 (33.8) | 1278 (37.2) | 9927 (20.4) | 12430 (22.3) | 261056 (26.4) |
| 35-44 | 605 (16.7) | 712 (20.7) | 16590 (34.1) | 17907 (32.1) | 208398 (21.1) |
| 45-54 | 169 (4.7) | 195 (5.7) | 13063 (26.8) | 13427 (24.1) | 147688 (14.9) |
| ≥ 55 | 44 (1.2) | 39 (1.1) | 6294 (12.9) | 6377 (11.4) | 155632 (15.8) |
| Median [IQR] | 26 [20-34] | 28 [22-35] | 42 [34-49] | 40 [32-48] | 35 [26-48] |
| Birth year | |||||
| < 1945 | 31 (0.9) | 35 (1.0) | 3102 (6.4) | 3168 (5.7) | 95848 (9.7) |
| 1945-1964 | 776 (21.4) | 1037 (30.2) | 32133 (66.0) | 33946 (60.9) | 310845 (31.5) |
| 1965-1974 | 1176 (32.4) | 1214 (35.3) | 9493 (19.5) | 11883 (21.3) | 209956 (21.2) |
| ≥ 1975 | 1645 (45.3) | 1150 (33.5) | 3989 (8.2) | 6784 (12.2) | 371732 (37.6) |
| Sex | |||||
| Female | 1728 (47.6) | 1380 (40.2) | 16741 (34.4) | 19849 (35.6) | 551952 (55.8) |
| Male | 1900 (52.4) | 2056 (59.8) | 31970 (65.6) | 35926 (64.4) | 436287 (44.1) |
| Unknown | 0 (0.0) | 0 (0.0) | 6 (0.0) | 6 (0.0) | 142 (0.0) |
| Year of diagnosis | |||||
| 1990-1994 | 85 (2.3) | 4 (0.1) | 3978 (8.2) | 4067 (7.3) | 3913 (0.4) |
| 1995-1999 | 726 (20.0) | 353 (10.3) | 17936 (36.8) | 19015 (34.1) | 104863 (10.6) |
| 2000-2004 | 1177 (32.4) | 939 (27.3) | 11733 (24.1) | 13849 (24.8) | 172888 (17.5) |
| 2005-2009 | 994 (27.4) | 1280 (37.3) | 9130 (18.7) | 11404 (20.4) | 272886 (27.6) |
| 2010-2013 | 646 (17.8) | 860 (25.0) | 5940 (12.2) | 7446 (13.4) | 433831 (43.9) |
| HIV/AIDS at baseline | |||||
| Unknown | 3450 (95.1) | 3207 (93.3) | 47568 (97.6) | 54225 (97.2) | 984182 (99.6) |
| Yes | 178 (4.9) | 229 (6.7) | 1149 (2.4) | 1556 (2.8) | 4199 (0.4) |
| HIV/AIDS (ever) | |||||
| Unknown | 3264 (90.0) | 3104 (90.3) | 46257 (95.0) | 52625 (94.3) | 983694 (99.5) |
| Yes | 364 (10.0) | 332 (9.7) | 2460 (5.0) | 3156 (5.7) | 4687 (0.5) |
| HBV at baseline | |||||
| No/Unknown | 3528 (97.2) | 3349 (97.5) | 48197 (98.9) | 55074 (98.7) | 974223 (98.6) |
| Yes | 100 (2.8) | 87 (2.5) | 520 (1.1) | 707 (1.3) | 14158 (1.4) |
| HBV (ever) | |||||
| No/Unknown | 3453 (95.2) | 3326 (96.8) | 46927 (96.3) | 53706 (96.3) | 968459 (98.0) |
| Yes | 175 (4.8) | 110 (3.2) | 1790 (3.7) | 2075 (3.7) | 19922 (2.0) |
| Active TB at baseline | |||||
| No/Unknown | 3621 (99.8) | 3428 (99.8) | 48634 (99.8) | 55683 (99.8) | 986909 (99.9) |
| Yes | 7 (0.2) | 8 (0.2) | 83 (0.2) | 98 (0.2) | 1472 (0.1) |
| Active TB (ever) | |||||
| No/Unknown | 3611 (99.5) | 3415 (99.4) | 48466 (99.5) | 55492 (99.5) | 986473 (99.8) |
| Yes | 17 (0.5) | 21 (0.6) | 251 (0.5) | 289 (0.5) | 1908 (0.2) |
| Material deprivation quintile at baseline | |||||
| Unknown | 96 (2.7) | 79 (2.3) | 2316 (4.8) | 2491 (4.5) | 14773 (1.5) |
| Q1 (most privileged) | 452 (12.5) | 444 (12.9) | 6247 (12.8) | 7143 (12.8) | 214007 (21.7) |
| Q2 | 526 (14.5) | 463 (13.5) | 7500 (15.4) | 8489 (15.2) | 187587 (19) |
| Q3 | 531 (14.6) | 585 (17.0) | 8522 (17.5) | 9638 (17.3) | 192265 (19.5) |
| Q4 | 876 (24.2) | 774 (22.5) | 10580 (21.7) | 12230 (21.9) | 197116 (19.9) |
| Q5 (most deprived) | 1147 (31.6) | 1091 (31.8) | 13552 (27.8) | 15790 (28.3) | 182633 (18.5) |
| Social deprivation quintile at baseline | |||||
| Unknown | 96 (2.7) | 79 (2.3) | 2316 (4.8) | 2491 (4.5) | 14773 (1.5) |
| Q1 (most privileged) | 271 (7.5) | 283 (8.2) | 5302 (10.9) | 5856 (10.5) | 180214 (18.2) |
| Q2 | 349 (9.6) | 337 (9.8) | 6194 (12.7) | 6880 (12.3) | 175098 (17.7) |
| Q3 | 540 (14.9) | 463 (13.5) | 8094 (16.6) | 9097 (16.3) | 175715 (17.8) |
| Q4 | 703 (19.4) | 720 (21.0) | 9972 (20.5) | 11395 (20.4) | 201551 (20.4) |
| Q5 (most deprived) | 1669 (46.0) | 1554 (45.2) | 16839 (34.6) | 20062 (36) | 241030 (24.4) |
| Mental health at baselined | |||||
| No/Unknown | 2199 (64.5) | 2096 (65.0) | 40934 (86.7) | 45229 (84.0) | 729398 (88.0) |
| Yes | 1209 (35.5) | 1130 (35.0) | 6297 (13.3) | 8636 (16.0) | 99054 (12.0) |
| Mental health 3yrs pre-baselined | |||||
| No/Unknown | 2590 (76.0) | 2653 (82.2) | 43518 (92.1) | 48761 (90.5) | 781042 (94.3) |
| Yes | 818 (24.0) | 573 (17.8) | 3713 (7.9) | 5104 (9.5) | 47410 (5.7) |
| Illicit drug use at baselined | |||||
| No/Unknown | 910 (26.7) | 942 (29.2) | 33036 (69.9) | 34888 (64.8) | 770499 (93.0) |
| Yes | 2498 (73.3) | 2284 (70.8) | 14195 (30.1) | 18977 (35.2) | 57953 (7.0) |
| Illicit drug use 3yrs pre-baselined | |||||
| No/Unknown | 1084 (31.8) | 1433 (44.4) | 36193 (76.6) | 38710 (71.9) | 795325 (96.0) |
| Yes | 2324 (68.2) | 1793 (55.6) | 11038 (23.4) | 15155 (28.1) | 33127 (4.0) |
| Problematic alcohol use at baselined | |||||
| No/Unknown | 2083 (61.1) | 1896 (58.8) | 38178 (80.8) | 42157 (78.3) | 777271 (93.8) |
| Yes | 1325 (38.9) | 1330 (41.2) | 9053 (19.2) | 11708 (21.7) | 51181 (6.2) |
| Problematic alcohol use 3yrs pre-baselined | |||||
| No/Unknown | 2521 (74.0) | 2555 (79.2) | 41709 (88.3) | 46785 (86.9) | 802492 (96.9) |
| Yes | 887 (26.0) | 671 (20.8) | 5522 (11.7) | 7080 (13.1) | 25960 (3.1) |
a24-month Sero: Individuals who seroconverted within 24 months of the last negative test
bIndividuals who seroconverted after 24 months of the last negative test
cBaseline is defined as date of diagnosis (i.e. first HCV positive test or case report) for HCV positive individuals, and date of last negative test result for HCV negative individuals
dMental health, drug misuse, alcohol misuse data was available up to 2012