Table 1.

Pharmacological properties of P2Y₁₂ inhibitors.^61,62

	Clopidogrel	Prasugrel	Ticagrelor
P2Y 12 binding	Irreversible	Irreversible	Reversible
Indication	ACS treated medically or with PCI, ischaemic stroke, peripheral artery disease	ACS post PCI	ACS
Dose	300–600 mg loading75 mg maintenance	60 mg loading dose, then 10 mg/day	180 mg loading dose, then 90 mg bd
		(5 mg if <60 kg)
Prodrug	Yes; needs hepatic metabolism	Yes; needs hepatic metabolism	No
Onset of action	2–8 hours	30 min – 4 hours	30 min – 4 hours
Elimination time	7–10 days	7–10 days	3–5 days
CYP metabolism	CYP2C19	CYP2C19	CYP3A4/5
ACS = acute coronary syndrome; PCI = percutaneous coronary intervention.