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A sustained cold-mediated TRPM8 activity induces necrosis of keratinoyctes. Images shows a Trypan blue staining of control HaCaT cells (CTL), eTRPM8-overexpressing HaCaT cells (eTRPM8) or HaCaT cells concomitantly overexpressing eTRPM8 and the superoxide dismutase 1, SOD1 (eTRPM8+SOD1) incubated at 37°C, 31°C or 25°C for 3 d. Necrotic cells appeared as dark blue-stained cells.
