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Role of irisin in the linkage of muscle to bone. Irisin is a myokine produced from skeletal muscle after exercise. It induces a browning response in white adipose tissues and protects from insulin resistance. In bone, irisin increases osteoblast differentiation through canonical Wnt-β-catenin, p38 MAPK and ERK pathways. On the other hand, irisin suppresses osteoclast differentiation through the suppression of RANKL/NFATc1 pathways.
