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Cell viability determined using the sulforhodamine B assay in (A) PNEC, (B) C4-2B, (C) PC-3, and (D) PC-3M prostate cancer cells demonstrate that niclosamide enhances cell toxicity with acidification. Statistical comparisons performed relative to pH 7.4 in each group. N = 4 samples per group. *p<0.05, **p>0.01, ***p<0.001. NV: Untreated PNEC and PC-3M cells are not viable at pH 6.0.
