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. 2016 Jul 20;11(7):e0158212. doi: 10.1371/journal.pone.0158212

Fig 9. Cross boosting of Pfs48/45 and Pvs48/45 antibody responses.

Fig 9

(A) Groups of mice were primed and boosted with the same antigen, either Pfs48/45 or Pvs48/45. Antibody titers were determined against both antigens by ELISA. The data shown are from mice after the booster immunization. (B) Shows results of mice primed with Pfs48/45 and boosted with Pvs48/45. Antibody titers were determined both after the primary and booster immunizations using ELISA plates coated with either Pfs48/45 or Pvs48/45. Antibody titers against Pfs48/45 between prime and boost were statistically significant (p = 0.0055). As shown, Pfs48/45 specific antibody titers after priming with Pfs48/45 were ≤ 100, we used a value of 100 for statistical comparison with titers after boost with Pvs48/45. (C) Shows results of mice primed with Pvs48/45 and boosted with Pfs48/45. Antibody titers were determined both after the primary and booster immunizations using plates coated with either antigen. Antibody titers against Pvs48/45 between prime and boost were statistically significant (p = 0.036). The geometric mean ELISA titer of each group is shown. Boxes above each column show number of positive mice / total mice tested. Statistical significance of the antibody titers between prime and boost were determined by Mann Whitney test with p value < 0.05, indicated by an asterisk (*).