Table 3. Identification of E180D mutations in azole resistant isolates.
Isolate | MIC (itraconazole) | MIC (mg/L) (voriconazole) | MIC (mg/L) (posaconazole) | Mutation in cyp51a | Mutation in 29.9 KD subunit |
---|---|---|---|---|---|
AF41 | 0.13 | 0.5 | 0.05 | nf | nf |
F11698 | 0.25 | 0.5 | 0.05 | nf | nf |
D17 | 0.5 | 0.5 | 0.05 | nf | nf |
JN10 | 0.5 | 0.5 | 0.25 | nf | nf |
AF10 | 0.5 | 0.5 | 0.5 | nf | nf |
AF1163 | 0.5 | 0.5 | 0.05 | nf | nf |
CEA10 | 0.5 | 0.5 | 0.05 | nf | nf |
SF2S9 | 0.5 | 1 | 0.25 | nf | nf |
SF3S1 | 0.5 | 1 | 0.25 | nf | nf |
SF3S10 | 0.5 | 1 | 0.25 | nf | nf |
M128 | 0.5 | 1 | 0.25 | nf | nf |
SF2S6 | 0.5 | 1 | 0.25 | nf | nf |
SF1S6 | 0.5 | 1 | 0.25 | nf | nf |
AF210 | 0.5 | 1 | 0.05 | nf | nf |
AP65 | 0.5 | 1 | 0.25 | nf | nf |
AF293 | 0.5 | 1 | 0.25 | nf | nf |
F5211 | 0.5 | 1 | 0.25 | nf | E180D |
AF300 | 0.5 | 1 | 0.05 | nf | nf |
SF1S5 | 0.5 | 1 | 0.05 | nf | nf |
SF4S10 | 0.5 | 1 | 0.05 | nf | E180D |
F12219 | 8 | 0.125 | 1 | G54R | nf |
AF72 | 8 | 0.5 | 1 | G54E | nf |
F14403 | 8 | 0.5 | 8 | G54R | nf |
F17582 | 8 | 1 | 0.25 | nf | E180D |
AF90 | 8 | 1 | 1 | M220V | nf |
F21572 | 8 | 1 | 1 | nf | E180D |
F7075 | 8 | 1 | 8 | G54E | E180D |
RSF2S8 | 8 | 4 | 0.05 | L98H/TR34 | nf |
F13619 | 8 | 8 | 0.5 | H147Y G448S | nf |
F13747 | 8 | 8 | 1 | G434C | nf |
F15122 | 8 | 8 | 1 | G448S | nf |
F16311 | 8 | 8 | 1 | nf | nf |
F12865 | 8 | 8 | 2 | G138C | E180D |
F13535 | 8 | 8 | 2 | G138C | E180D |
F16216 | 8 | 8 | 2 | L98H/TR34 | E180D |
F13746 | 8 | 8 | 2 | G138C | nf |
D1357 | 8 | 8 | 8 | L98H/TR34 | E180D |
F11628 | 8 | 8 | 8 | G138C | E180D |
F12041 | 8 | 8 | 8 | G138C | E180D |
F13952 | 8 | 8 | 8 | G138C | E180D |
F14513 | 8 | 8 | 8 | G138C | E180D |
F14946 | 8 | 8 | 8 | G138C | E180D |
Nf, none found.