Table 2. The other characteristics of the 7 studies included in the meta-analysis of the diagnostic performance of the anti-CarP antibody in rheumatoid arthritis.
Author [Reference] | Antigen | Type | RA | Healthy control | Control participants | Cut-off | TP | FP | FN | TN | SEN | SPE | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Female | Median age (yrs) | Female | Median age (yrs) | |||||||||||
Shi et al. [11] | FCS | IgG | NR | NR | NR | NR | Healthy | 2SD | 250 | 9 | 307 | 296 | 44.9% | 97.0% |
Montes et al. [15] | FCS | IgG | 76.9% | 63 | approximately 50% | 63 | Healthy | 2SD | 188 | 10 | 332 | 198 | 36.2% | 95.2% |
Challener et al. [16] | FCS | IgG | 70.3% | Approximately 57 | NR | NR | Healthy | 2SD | 81 | 3 | 131 | 62 | 38.2% | 95.4% |
Brink et al. [17] | FCS | IgG | 75% | 57.5 | 73.1% | 57.5 | healthy | a specificity of 97% of ROC curves | 81 | 7 | 111 | 190 | 42.2% | 96.4% |
Janssen et al. [18] | FCS | IgG | 56% | 57 | 60% | 26 | healthy, periodontitis, bronchiectasis, cystic fibrosis | 2SD | 41 | 10 | 45 | 261 | 47.7% | 96.3% |
Alessandri et al. [19] | FCS | IgG | 41% | 57.1 | NHS: 45% HFDRs: 42% | NHS: 44.6 HFDRs: 54.6 | healthy, healthy first-degree relatives of RA patients | 3SD | 29 | 14 | 34 | 183 | 46.0% | 92.9% |
Verheul et al. [20] | FCS | IgG | NR | NR | NR | NR | healthy | a specificity of 97% | 121 | 10 | 147 | 314 | 45.1% | 96.9% |
CarP = carbamylated protein; NR=Not reported; NHS= normal healthy subjects; HFDRs= healthy first-degree relatives; FCS=fetal calf serum; RA = rheumatoid arthritis; 2SD/3SD= the cut-off for a positive response as the mean plus two/three times the SD of the specific anti-CarP reactivity of the healthy control cohort; ROC= receiver operating characteristic; TP= true positive; FP= false positive; FN= false negative; TN= true negative; SEN=sensitivity; SPE=specificity