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. 2016 Jul 20;11(7):e0159000. doi: 10.1371/journal.pone.0159000

Table 2. The other characteristics of the 7 studies included in the meta-analysis of the diagnostic performance of the anti-CarP antibody in rheumatoid arthritis.

Author [Reference] Antigen Type RA Healthy control Control participants Cut-off TP FP FN TN SEN SPE
Female Median age (yrs) Female Median age (yrs)
Shi et al. [11] FCS IgG NR NR NR NR Healthy 2SD 250 9 307 296 44.9% 97.0%
Montes et al. [15] FCS IgG 76.9% 63 approximately 50% 63 Healthy 2SD 188 10 332 198 36.2% 95.2%
Challener et al. [16] FCS IgG 70.3% Approximately 57 NR NR Healthy 2SD 81 3 131 62 38.2% 95.4%
Brink et al. [17] FCS IgG 75% 57.5 73.1% 57.5 healthy a specificity of 97% of ROC curves 81 7 111 190 42.2% 96.4%
Janssen et al. [18] FCS IgG 56% 57 60% 26 healthy, periodontitis, bronchiectasis, cystic fibrosis 2SD 41 10 45 261 47.7% 96.3%
Alessandri et al. [19] FCS IgG 41% 57.1 NHS: 45% HFDRs: 42% NHS: 44.6 HFDRs: 54.6 healthy, healthy first-degree relatives of RA patients 3SD 29 14 34 183 46.0% 92.9%
Verheul et al. [20] FCS IgG NR NR NR NR healthy a specificity of 97% 121 10 147 314 45.1% 96.9%

CarP = carbamylated protein; NR=Not reported; NHS= normal healthy subjects; HFDRs= healthy first-degree relatives; FCS=fetal calf serum; RA = rheumatoid arthritis; 2SD/3SD= the cut-off for a positive response as the mean plus two/three times the SD of the specific anti-CarP reactivity of the healthy control cohort; ROC= receiver operating characteristic; TP= true positive; FP= false positive; FN= false negative; TN= true negative; SEN=sensitivity; SPE=specificity