Table 1.

Prioritized ER proteostasis regulators.

DOI: http://dx.doi.org/10.7554/eLife.15550.009

Name	Structure	MW	Polar Surface Area	AlogP	Structural moieties (Figure 1—figure supplement 1B–C)	% ERSE-FLuc activation*	% XBP1-RLuc activation*	Promiscuity**
5		271.2	41.13	2.62	-	60.9 ± 6.0	9.1 ± 0.7	1 out of 31
132		283.3	58.56	3.27	F	140.1 ± 17.4	10.3 ± 7.9	2 out of 32
145		260.3	75.36	3.01	F, H	83.4 ± 6.3	24.5 ± 4.7	1 out of 31
147		255.3	49.33	3.35	B, F	63.2 ± 0.6	17.5 ± 1.9	1 out of 32
148		322.3	149.12	2.00	B, F	52.5 ± 14.3	16.6 ± 2.4	3 out of 31
238		314.7	69.64	2.94	B, L	68.2 ± 5.7	61.1 ± 0.1.5	2 out of 31
258		393.2	91.15	3.76	C, D	28.6 ± 6.1	32.6 ± 1.0	1 out of 31
263		257.2	90.44	3.10	C	20.7 ± 2.3	2.4 ± 1.0	1 out of 31

*% Tg activation from triplicate confirmation screen at 6.8 μM.

** Number of screening assays in which the compound was found active.