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| Previous immunization | Antigen | Antigen dose (μg) | Adjuvant | TLR7 agonist dose (μg) |
SBA |
|
|---|---|---|---|---|---|---|
| Post 1 | Post2 | |||||
| – | <16 | <16 | ||||
| – | CRM-MenC | 1 | Alum | 128 | 2048 | |
| – | CRM-MenC | 1 | Alum/TLR7 | 10 | 2048 | 32768 |
| TdaP | <16 | <16 | ||||
| TdaP | CRM-MenC | 1 | Alum | <16 | 4096 | |
| TdaP | CRM-MenC | 1 | Alum/TLR7 | 10 | 1024 | 16384 |
