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. 2016 Jul 21;6:30129. doi: 10.1038/srep30129

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Copyright © 2016, Macmillan Publishers Limited

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(A) Number of primordial follicles in the rat ovary shows no significant change after HupA treatment. (B) No change of the primary follicle count was observed in HupA group compared to control. (C) HupA treatment of the rat ovary trends to result in an increased occurrence of secondary follicles. (D) Values for the number of secondary follicles corresponding to the mean diameter revealed an increase of small secondary follicles (60–99 μm) after HupA exposure. All values are shown as mean + S.E.M. of n = 5 (control) and n = 4 (HupA) individual rats (**P < 0.01).