Table 1. Serum metabolic parameters in db/db mice with or without CR.
| Metabolic parameters | db/m (n = 10) | db/db (n = 10) | db/db+CR (n = 10) |
|---|---|---|---|
| Insulin (ng/mL) | 0.98 ± 0.22 | 5.43 ± 1.94* | 1.17 ± 0.24† |
| Leptin (ng/mL) | 15.22 ± 1.79 | 41.09 ± 4.08* | 26.60 ± 2.92† |
| Adiponectin (μg/mL) | 8107.44 ± 848.93 | 7685.24 ± 669.70 | 9925.84 ± 414.03† |
| AST (U/L) | 77.20 ± 8.15 | 248.89 ± 48.60* | 120.80 ± 16.01† |
| ALT (U/Ll) | 29.00 ± 1.62 | 234.00 ± 54.77* | 66.40 ± 11.14† |
| Glucose (mg/dL) | 396.50 ± 30.68 | 864.00 ± 87.52* | 851.10 ± 69.01 |
| Total cholesterol (mg/dL) | 93.00 ± 7.48 | 214.67 ± 18.05* | 98.40 ± 7.82† |
| Triglyceride (mg/dL) | 70.60 ± 7.76 | 163.89 ± 11.71* | 123.10 ± 13.34† |
| Free fatty acid (μEq/L) | 1100.00 ± 101.85 | 1930.89 ± 206.23* | 1839.50 ± 152.69 |
Data are presented as the mean ± SEM. *P < 0.05 for db/db mice vs. db/m mice, †P < 0.05 for db/db+CR vs. db/db mice. AST, aspartate aminotransferase; ALT, alanine aminotransferase; CR, caloric restriction.