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. 2016 Jul 21;6:30127. doi: 10.1038/srep30127

Figure 4. Neuroprotective effect of FK506-liposomes against I/R injury.

Figure 4

t-MCAO rats were intravenously injected with FK506-liposomes (100 μg/kg FK506 equivalent) or PBS immediately after reperfusion. Seven days after reperfusion, 10-μm frozen brain sections were prepared and immunostained for NeuN (green) and counterstained nuclei with DAPI (blue). The fluorescence images of the striatum (a) and the cortex (b) were obtained by confocal laser scanning microscopy. Isc and non-isc indicate ischemic and non-ischemic areas, respectively. Scale bar, 50 μm. Quantitative data from confocal images were obtained by counting NeuN-positive cells in the sections (c). Data are presented as the mean ± S.D. (n = 5). Significance of differences: *P < 0.05, ***P < 0.001 vs. PBS.