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. 2016 Apr 27;185(2):165–179. doi: 10.1111/cei.12780

Figure 4.

Figure 4

Cellular responses of recombinant Leishmania donovani S‐adenosyl‐L‐homocysteine hydrolase (rLdAdoHcy) + bacillus Calmette–Guérin (BCG)‐vaccinated hamsters. (I) Lymphocyte transformation test (LTT) response [mean optical density (OD) values] to concanavalin A (ConA) and rLdAdoHcy in normal, infected and BCG controls as well as in vaccinated animals on days 45, 60 and 90 post‐challenge (p.c.). (II) Nitric oxide (NO) production (µM) to lipopolysaccharide (LPS) and rLdAdoHcy in the naive macrophages co‐incubated with supernatants of mononuclear cells isolated from normal, infected controls and BCG controls as well as rLdAdoHcy + BCG‐vaccinated hamsters on days 45, 60 and 90 p.c. Significance values indicate the difference between the vaccinated and infected groups (*P < 0·05; **P < 0·01; ***P < 0·001).