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. 2016 Apr 27;185(2):165–179. doi: 10.1111/cei.12780

Figure 5.

Figure 5

Cellular responses of recombinant Leishmania donovani S‐adenosyl‐L‐homocysteine hydrolase (rLdAdoHcy) + bacillus Calmette–Guérin (BCG)‐vaccinated hamsters. (I) Delayed‐type hypersensitivity (DTH) response (mm) to soluble L. donovani (SLD) antigen as footpad swelling on days 45, 60 and 90 post‐challenge (p.c). Significance values indicate the difference between the vaccinated and infected groups (*P < 0·05; **P < 0·01; ***P < 0·001). (II) Serological response in rLdAdoHcy + BCG‐vaccinated hamsters: immunoglobulin (Ig)G and its isotypes IgG1 and IgG2 response in rLdAdoHcy‐vaccinated hamsters in comparison to the unvaccinated infected control hamsters on days 45, 60 and 90 p.c. Significance values indicate the difference between the vaccinated and unvaccinated infected groups (*P < 0·05; **P < 0·01; ***P <0·001).