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. 2016 Jun 23;6(10):1703–1716. doi: 10.7150/thno.15647

Figure 6.

Figure 6

In vivo pharmacokinetics and biodistribution studies of Gd(DTPA-CPT) nanoparticles. (a) Blood elimination profiles of Gd(DTPA-CPT) nanoparticles and Gd(DTPA) following a single intravenous injection into rats at a dose of 0.10 mmol kg-1. Data represent mean ± SD (n = 4). (b) Biodistribution of Gd(DTPA-CPT) nanoparticles and Gd(DTPA) in various tissues after 0.5 h, 5 h and 18 h post-injection (0.10 mmol kg-1) into nude mice bearing LoVo tumors. Data represent mean ± SD (n = 4). Statistical significance: *, P < 0.05.