Table 6.
Quantification of incorporated dTG (amount detected in 50 μL sample, representing 0.18 μg DNA, injected onto column) in NBC in relation to clinical parameters from patients (ID 1–20) treated with azathioprine (dose) and three untreated patients (A–C). ID, patient identifier; N/A, data not available; N/D, analyte not detected.
| ID | Diseasea | dose | ng dAb | ng dTG | moles dTG/106 moles dA | fmoles dTG/μg DNA | WCCc | Neutc | ALTc | APc | TPMT | RBC TGNc | RBC MMPc |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CD | 100 | 3.97 | 0.003 | 59.2 | 52.0 | 10.9 | 9.4 | 10 | 60 | 70 | N/A | N/A |
| 2 | UC | 150 | 9.25 | 0.035 | 333.2 | 682.2 | 5.4 | 3.3 | 20 | 50 | 70 | N/A | N/A |
| 3 | UC | 150 | 3.115 | 0.001 | 20.2 | 13.9 | 4.3 | 3 | 29 | 89 | 87 | N/A | N/A |
| 4 | UC | 125 | 7.4 | 0.011 | 135.4 | 221.8 | 3.8 | 2.4 | 5 | 42 | 14 | N/A | N/A |
| 5 | CD | 200 | 4.62 | 0.027 | 524.1 | 535.9 | 3.4 | 2.2 | 21 | 37 | 70 | N/A | N/A |
| 6 | UC | 150 | 4.555 | 0.005 | 97.4 | 98.2 | 9.3 | 5.1 | 16 | 94 | 123 | N/A | N/A |
| 7 | CD | 150 | 14.7 | 0.022 | 133.3 | 433.8 | 5.5 | 3.6 | 13 | 52 | 102 | N/A | N/A |
| 8 | UC | 100 | 6.1 | 0.003 | 36.3 | 49.1 | 5 | 3 | 13 | 70 | 78 | N/A | N/A |
| 9 | CD | 100 | 4.185 | 0.004 | 74.2 | 68.7 | 9 | 8 | 11 | 63 | 80 | N/A | N/A |
| 10 | CD | 50 | 7.35 | 0.002 | 26.5 | 43.2 | 10.5 | 8.3 | 18 | 91 | 102 | N/A | N/A |
| 11 | UC | 150 | 11.4 | 0.006 | 46.7 | 117.8 | 8 | 4 | 15 | 86 | 81 | 148 | 412 |
| 12 | UC | 200 | 6.2 | 0.013 | 178.8 | 245.4 | 5.8 | 4.1 | 22 | 71 | N/A | 296 | 6698 |
| 13 | CD | 42 | 11.95 | 0.024 | 181.1 | 479.0 | 5 | 2.9 | 14 | 16 | N/A | 522 | 0 |
| 14 | UC | 25 | 5.15 | 0.008 | 129.2 | 147.2 | 3.8 | 2.7 | 16 | 78 | N/A | 318 | 0 |
| 15 | CD | 200 | 6.45 | 0.002 | 27.5 | 39.3 | 9.2 | 9 | 8 | 80 | 94 | 559 | 0 |
| 16 | CD | 150 | 4.77 | 0.005 | 89.3 | 94.2 | 8 | 5.7 | 16 | 64 | 92 | 120 | 221 |
| 17 | UC | 175 | 1.785 | 0.019 | 921.7 | 364.2 | 7.8 | 5.7 | 13 | 58 | N/A | 293 | 363 |
| 18 | UC | 100 | 7.2 | 0.032 | 393.6 | 627.2 | 3.3 | 2.4 | 15 | 80 | 116 | 477 | 219 |
| 19 | CD | 75 | 14.45 | 0.007 | 44.5 | 142.3 | 6.3 | 4 | 15 | 100 | 100 | 80 | 320 |
| 20 | CD | 200 | 3.125 | 0.048 | 1359.5 | 940.3 | 5.1 | 3 | 28 | 45 | 94 | 169 | 6398 |
| A | UC | 0 | 10 | N/D | N/D | N/D | 4.6 | 3.2 | 26 | 202 | 126 | N/A | N/A |
| B | UC | 0 | 9.6 | N/D | N/D | N/D | 3.6 | 2.3 | 19 | 52 | 134 | N/A | N/A |
| C | CD | 0 | 8.45 | N/D | N/D | N/D | 12.3 | 10.2 | 20 | 85 | 81 | N/A | N/A |
Crohn’s Disease, CD; Ulcerative colitis UC.
Representing 0.018 μg DNA injected.
Normal ranges: White cell count (WCC), 4–11 × 109/L; Neutrophils (Neut), 2.5–7.5 × 109/L; Alanine aminotransferase (ALT), 7–56 U/L; Alkaline Phosphatase (AP), 44–147 IU/L; TPMT, 70–110 mU/L; RBC TGNs, reference range 235–450 pmol/8 × 108 RBC.