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. 2016 Jul 20;16:511. doi: 10.1186/s12885-016-2542-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Thiostrepton reduced FOXM1 expression in the SS cell lines, producing diminished cell viability. a SS cell lines treated with 1 μM thiostrepton for 48 h and 72 h showed decreased FOXM1 protein on Western blots. b Treatment of SS cell lines with increasing quantities of Thiostrepton for 72 h resulted in reduced numbers of viable cells compared to diluent controls. c and d Proliferation of SS cell lines treated with 1 μM thiostrepton, 5 ng/mL DOX, or their combination. The cell lines treated with the combination of both drugs showed lower proliferation than those treated with each drug individually (c: SYO-I, d: HS-SY-II). *P < 0.05 by Steel-Dwass multiple comparison test