Table 1.
Association of clinical characteristics and pathological factors with early recurrence
| Variables | Early recurrence | P | ||
|---|---|---|---|---|
| No | Yes | |||
| Age | ≤50 | 15 | 8 | 0.365 |
| >50 | 20 | 6 | ||
| Sex | male | 26 | 10 | 0.838 |
| female | 9 | 4 | ||
| HBsAg | Negative | 7 | 2 | 0.641 |
| Postive | 28 | 12 | ||
| HBeAg | Negative | 27 | 9 | 0.357 |
| Postive | 8 | 5 | ||
| HBVDNA | <5*102 | 21 | 10 | 0.453 |
| >5*102 | 14 | 4 | ||
| ALT (U/L) | ≤40 | 30 | 9 | 0.412 |
| >40 | 5 | 5 | ||
| AFP (ng/ml) | ≤400 | 23 | 10 | 0.768 |
| >400 | 12 | 4 | ||
| EpCAM mRNA+ CTC (2-ΔΔCq) | Low (<2.22) | 28 | 4 | <0.001* |
| High (≥2.22) | 7 | 10 | ||
| Treg/CD4+ (%) | <5.07 | 31 | 9 | 0.020* |
| ≥5.07 | 4 | 5 | ||
| Child-Pugh stage | A | 34 | 14 | 0.523 |
| B | 1 | 0 | ||
| Liver cirrhosis | No | 9 | 3 | 0.753 |
| Yes | 26 | 11 | ||
| Tumor number | Single | 33 | 11 | 0.101 |
| Multiple | 2 | 3 | ||
| Tumor size (cm) | ≤5 | 21 | 8 | 0.854 |
| >5 | 14 | 6 | ||
| Tumor encapsulation | Complete | 16 | 5 | 0.523 |
| None | 19 | 9 | ||
| Satellite lesion | No | 34 | 10 | 0.007* |
| Yes | 1 | 4 | ||
| Vascular invasion | No | 21 | 4 | 0.047* |
| Yes | 14 | 10 | ||
| Edmondson stage | I-II | 22 | 9 | 0.925 |
| II-IV | 13 | 5 | ||
| BCLC stage | 0 + A | 33 | 11 | 0.101 |
| B + C | 2 | 3 | ||
Abbreviations: ALT alanine transaminase, HBsAg Hepatitis B surface antigen, AFP alphafetoprotein, HBeAg Hepatitis B e antigen. p value of < 0.05 was considered statistically-significant