Table 5.
Analyses of risk factors for HCC recurrence
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95 % CI) | P | HR (95 % CI) | P | |
| Age (>50y vs. ≤ 50y) | 0.626 (0.217–1.804) | 0.385 | N.A. | |
| Gender (Male vs. Female) | 0.886 (0.278–2.827) | 0.838 | N.A. | |
| HBsAg (Positive vs. Negative) | 1.433 (0.321–6.406) | 0.638 | N.A. | |
| Cirrhosis (Positive vs. Negative) | 1.323 (0.369–4.743) | 0.668 | N.A. | |
| Child-Pugh grade (B vs. A) | 0.048 (0.000–23944) | 0.700 | N.A. | |
| ALT (>40 U/L vs. ≤ 40 U/L) | 0.783 (0.246–2.497) | 0.679 | N.A. | |
| AFP (>400 ng/ml vs. ≤ 400 ng/ml) | 2.258 (0.756–6.743) | 0.145 | N.A. | |
| Tumor number (multiple vs. one) | 3.570 (0.998–12.896) | 0.052 | N.A. | |
| Tumor size (>5 cm vs. ≤5 cm) | 1.094 (0.379–3.154) | 0.868 | N.A. | |
| Tumor encapsulation (Yes vs. No) | 1.425 (0.477–4.252) | 0.526 | N.A. | |
| Satellite lesion (Yes vs. No) | 5.726 (1.771–18.509) | 0.004 | 5.917 (1.342–26.078) | 0.019 |
| Vascular invasion (Yes vs. No) | 2.943 (0.922–9.399) | 0.068 | N.A. | |
| Edmondson classification (III-IV vs. I-II) | 1.057 (0.354–3.155) | 0.921 | N.A. | |
| BCLC stage (B + C vs. 0 + A) | 3.496 (0.966–12.646) | 0.056 | N.A. | |
| EpCAM+ CTC 2-ΔΔCq (≥2.22 vs. < 2.22) | 6.580 (2.056–21.055) | 0.001 | 6.668 (1.943–22.883) | 0.003 |
| Treg/CD4+(≥5.07 vs. < 5.07) | 2.993 (0.998–8.947) | 0.045 | 0.825 (0.196–3.468) | 0.792 |