Skip to main content
. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Genes Brain Behav. 2016 Jul;15(6):604–615. doi: 10.1111/gbb.12302

Figure 2. Significant QTLs associated with mechanical sensitivity were identified on Chr 5 (panel a) and Chr 15 (panel b).

Figure 2

Interval mapping of von Frey mechanical threshold means of BXD RI mice indicate in (a) a significant QTL on proximal Chr 5 (peak LOD score = 4.0; only 0–50 Mb from centromere shown) and in (b) a significant QTL on distal Chr 15 (peak LOD score = 4.2; only 50–103 Mb from centromere shown). The 95% CIs of the QTLs (based on a 1.0 LOD drop-off from the peak) indicate that polymorphic genes responsible for variation in mechanical sensitivity are located in the genomic regions from 4.468 to 19.63 Mb on Chr 5 and from 74.791 to 79.503 Mb on Chr 15. The dotted lines indicate the significant LOD score threshold of 3.76 determined by 1000 permutations of the strain means and a genome-wide error rate of 0.05. Vertical hatch marks on the x-axis indicate DNA marker positions. Arrowheads indicate the position of the candidate genes Cacna2d1 and Csnk1e on Chr 5 and Chr 15, respectively.