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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Genes Brain Behav. 2016 Jul;15(6):604–615. doi: 10.1111/gbb.12302

Figure 6. The CK-1δ/ε inhibitor dose-dependently decreases mechanical sensitivity with differential effectiveness observed between C57BL/6J (n = 6–9; filled circles) and DBA/2J (n = 7–9; open triangles) strains.

Figure 6

These strains show significant differences in expression of Csnk1e (see Tables 1 and 2). PF-670462 produced a dose-dependent increase in von Frey thresholds in both parental strains (P < 0.0001). The effect was significantly greater in DBA/2J mice (P < 0.05). The lowest dose administered (20 mg/kg) was effective only in DBA/2J mice (P < 0.05). Threshold change is plotted for clarity as vehicle-treated C57BL/6J mice exhibited greater mechanical thresholds than vehicle-treated DBA/2J mice (1.3 ± 0.3 vs. 1.2 ± 0.2 g; P < 0.05). Error bars represent SEM.