Skip to main content
. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2016 May 5;26(13):3029–3033. doi: 10.1016/j.bmcl.2016.05.010

Figure 2.

Figure 2

Structure and key biological data for the M4 PAM HTS hit VU0473619 (5), and three areas to address in the lead optimization campaign. Potency values represent means from at least three independent determinations in a functional Ca2+ mobilization assay with rat or human M4/Gqi5-CHO cells performed in the presence of an ~EC20 fixed concentration of acetylcholine.