Figure 1.

Dynamic balance between actomyosin contractility and cell-cell (A) and cell-ECM (B) adhesion forces determines different cell migration modes. (A) Increase in actomyosin contractility leads to disruption of the collective migration and an emergent single cell motility for both low and high cell-cell adhesion. (B) For low cell-ECM adhesion the amoeboid migration is preferred, while for the higher adhesion (and stiffness) the lamellipodia-based migration is selected, but it can be replaced by the lobopodial migration in 3D stiff environment.