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In vivo Rat PK IV clearance (1 mg/kg)
| 11r | 11t | ||
|---|---|---|---|
| CL (mL/min/kg) | 37.2 | 86.8 | |
| T1/2 (min) | 252 | 167 | |
| MRT (min) | 149 | 84.7 | |
| Vss (L/kg) | 5.5 | 7.4 | |
| AUC (h ng/mL) | 447.5 | 191.7 | |
| po dosing of 11t with and without ABT, 1 h | |||
| Dose (mg/kg) | Concentration (ng/mg or g) | ||
| Plasma systemic | Plasma HPV | Brain | |
| 10/Veh | 7.4 | 731 | 8.1 |
| 10/ABT | 198.5 | 764.5 | 175.5 |
