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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: J Med Chem. 2015 Mar 30;58(7):3002–3024. doi: 10.1021/jm501440q

Table 4.

EMSA-determined disruption of ternary c-Myc–Max(S)/DNA and Max(L)–Max(L)/DNA complexes by synthetic α-helix mimetics. Each IC50 and standard error were calculated based on three independent EMSAs performed for each compound concentration tested (Supplementary Figure 1).

Code Number Inhibition (IC50, µM)
c-Myc-Max(S)/DNA Max(L)-Max(L)/DNA
4aa 20.2 ± 1.3 84.9 ± 12.0
4da 11.6 ± 2.3 >20
4ca 43.0 ± 1.7 79.0 ± 8.5
15 43.8 ± 2.9 >100
16 23.8 ± 2.7 68.7 ± 4.5
21 5.6 ± 0.7 >12.5