Table 5.
Viability of HL60 and Daudi cells in the presence of synthetic α-helix mimetics after 3 days. MTT cell proliferation assays performed as previously described.37,38,45,48,49 The results shown represent the means and standard deviations of quadruplicate experiments.
| Code Number | Inhibition (IC50, µM) | |
|---|---|---|
| HL60 Cells | Daudi Cells | |
| 4aa | 39.9 ± 5.3 | 22.9 ± 2.5 |
| 4da | 19.9 ± 1.6 | 9.5 ± 0.7 |
| 4ca | 44.8 ± 0.9 | 25.6 ± 1.4 |
| 15 | 21.5 ± 2.7 | 11.2 ± 1.4 |
| 16 | 30.3 ± 4.6 | 11.1 ± 1.1 |
| 21 | >50 | >50 |