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. Author manuscript; available in PMC: 2016 Jul 21.
Published in final edited form as: J Med Chem. 2015 Mar 30;58(7):3002–3024. doi: 10.1021/jm501440q

Table 5.

Viability of HL60 and Daudi cells in the presence of synthetic α-helix mimetics after 3 days. MTT cell proliferation assays performed as previously described.37,38,45,48,49 The results shown represent the means and standard deviations of quadruplicate experiments.

Code Number Inhibition (IC50, µM)
HL60 Cells Daudi Cells
4aa 39.9 ± 5.3 22.9 ± 2.5
4da 19.9 ± 1.6 9.5 ± 0.7
4ca 44.8 ± 0.9 25.6 ± 1.4
15 21.5 ± 2.7 11.2 ± 1.4
16 30.3 ± 4.6 11.1 ± 1.1
21 >50 >50