Table 2.
Cognitive Test Scores at the time of PiB PET imaging
| Cognitive scoresa | Oral CEE (N = 17) | Transdermal 17β-Estradiol (N = 21) | Placebo (N = 30) | p-valuesb |
| NYU Paragraph Immediate Recall Total Score | 25 (16, 33) | 26 (15, 39) | 24 (17, 40) | 0.86 |
| NYU Delayed Recall Total Score | 16 (5, 24) | 14 (7, 23) | 14 (9, 32) | 0.88 |
| CVLT-II Trials 1–3 Total Score | 29 (16, 36) | 33 (25, 42) | 31 (14, 43) | 0.03* |
| CVLT-II Trial Short Delay Free Recall score | 10 (3, 16) | 12 (7, 16) | 11 (4, 16) | 0.06 |
| CVLT-II Trial Long Delay Free Recall score | 9 (3, 15) | 11 (6, 15) | 10 (4, 16) | 0.19 |
| WMS-III Digit Span Total Score | 15 (10, 22) | 18 (10, 26) | 17 (8, 26) | 0.20 |
| WMS-III Letter Number Sequencing Trial Total Score | 10 (6, 14) | 11 (6, 15) | 10 (7, 17) | 0.50 |
| Trail Making Test A (Time to complete in seconds) | 24 (15, 44) | 23 (15, 43) | 24 (15, 39) | 0.89 |
| Trail Making Test B (Time to complete in seconds) | 56 (33, 83) | 59 (35, 249) | 57 (33, 135) | 0.85 |
| Phonemic Fluency (F,A,S) Total Score | 44 (27, 69) | 43 (19, 59) | 46 (22, 77) | 0.40 |
| Semantic Fluency (animals, fruits, vegetables) Total Score | 56 (30, 77) | 55 (38, 68) | 52 (36, 71) | 0.35 |
| Stroop Trial Word | 99 (69, 136) | 105 (70, 120) | 100 (69, 140) | 0.95 |
| Stroop Trial Color | 78 (61, 96) | 74 (60, 110) | 75 (58, 101) | 0.55 |
| Stroop Trial Color-Word | 43 (18, 58) | 44 (31, 61) | 46 (21, 78) | 0.78 |
| Digit Symbol Total Score | 82 (57, 93) | 83 (61, 108) | 82 (64, 103) | 0.09 |
aData shown are median (range) of raw scores. bp-values were assessed using Analysis of Variance adjusting for age at PiB PET, levels of education, time from menopause to randomization (months) and APOE ɛ4 carrier status. *Tukey Honest significant differences test for post hoc comparisons: Oral CEE versus placebo (p = 0.03); CEE versus transdermal17β-estradiol (p = 0.08); transdermal17β-estradiol versus placebo (p = 0.98).