Table 2.
Survival Analysis in Cholangiocarcinoma Patients
| Overall Survival
|
|||||
|---|---|---|---|---|---|
| Univariate analysis (Log-rank)
|
Multivariate analysis (Cox regression)
|
||||
| Median time, wk±SE | p | Hazard ratio | 95%CI | p | |
| Gender | 0.04 | 0.011 | |||
| Male | 29.00±1.99 | 1 | |||
| Female | 40.14±4.01 | 0.66 | 0.48–0.91 | ||
| Age | NS | NS | |||
| ≤56 | 35.00±4.12 | 1.10 | 0.82–1.48 | ||
| >56 | 30.00±3.70 | 1 | |||
| Gross type | NS | N/A | |||
| Mass forming | 32.00±3.29 | ||||
| Periductal infiltrating | 32.29±8.08 | ||||
| Intraductal growth | 87.90±14.61 | ||||
| Tumor size | NS | NS | |||
| ≥5 cm | 36.70±2.96 | 0.97 | 0.72–1.31 | ||
| >5 cm | 29.57±2.95 | 1 | |||
| Tumor direct invasion | 0.02 | ||||
| Absent | 37.14±4.90 | 1 | |||
| Present | 27.42±1.66 | 1.40 | 0.94–2.08 | ||
| Vascular invasion | 0.04 | NS | |||
| Absent | 37.14±3.81 | 1 | |||
| Present | 25.42±1.99 | 1.11 | 0.82–1.52 | ||
| Histology group | 0.03 | NS | |||
| Less diff. | 29.00±2.63 | 1 | |||
| Well diff. | 41.14±6.47 | 0.80 | 0.59–1.08 | ||
| Lymphatic permeation | 0.001 | 0.004 | |||
| Absent | 38.14±3.06 | 1 | |||
| Present | 25.42±1.95 | 1.67 | 1.17–2.39 | ||
| Perineural invasion | NS | NS | |||
| Absent | 29.57±4.40 | 1 | |||
| Present | 29.28±2.34 | 1.06 | 0.77–1.45 | ||
| Lymph node metastasis | 0.033 | 0.037 | |||
| Absent | 32.14±6.31 | 1 | |||
| Present | 26.57±4.09 | 1.37 | 1.01–1.85 | ||
| OPN expression in cancer cells | NS | NS | |||
| Absent | 33.30±3.35 | 1 | |||
| Present | 33.57±3.54 | 0.79 | 0.52–1.19 | ||
| OPN expression in stroma | NS | NS | |||
| Absent | 30.42±4.11 | 1 | |||
| Present | 34.57±3.87 | 0.87 | 0.64–1.17 | ||
*
CI = Confident interval, NS = No significant different, N/A = Not applicable, diff = differentiate