Figure 4. An extra copy of p53 blocks Kras^G12D-mutant lung tumor development.

Representative hematoxylin and eosin–stained sections of unirradiated lungs from (A) an LA-1; WT p53 mouse and (B) an LA-1; super p53 mouse. Images were obtained at ×25 magnification. Quantification of (C) tumor burden, (D) normalized tumor number, and (E) average tumor size in unirradiated LA-1; WT p53 and LA-1; super p53 mice. Each symbol represents 1 mouse. *P < 0.05 by Mann-Whitney test.