Table 1.
Summary of Studies Included in Review
| Study | Journal | Primary Focus | No. of Subjects | Defect | CPM Regimen |
|---|---|---|---|---|---|
| Salter et al.29 | J Bone Joint Surg Am (1980) | Histology | 147 | Full-thickness OCD | 40°–110° of flexion; 1 cycle/40 s; 1, 2, 3, or 4 wk |
| Salter et al.47 | Clin Orthop Relat Res (1981) | Histology | 60 | Staphylococcus aureus septic arthritis | 40°–110° of flexion; 1 cycle/40 s; 24 h/d × 2 wk |
| O’Driscoll and Salter51 | J Bone Joint Surg Am (1984) | Histology | 30 | Free periosteal autograft (intercondylar notch) | 40°–110° of flexion; 1 cycle/40 s |
| O’Driscoll et al.41 | J Bone Joint Surg Am (1986) | Histology | 143 | Periosteal autograft in full-thickness OCD (trochlea) | 40°–110° of flexion; 2 wk and 4 wk |
| O’Driscoll and Salter42 | Clin Orthop Relat Res (1986) | Histology | 55 | Periosteal autograft in OCD (medial femoral condyle) | 40°–110° of flexion; 1 cycle/40 s; 2 wk of CPM followed by 4 wk of IAM |
| O’Driscoll et al.46 | J Bone Joint Surg Am (1988) | Histology | 45 | Periosteal autograft in full-thickness OCD (trochlea) | 40°–110° of flexion; 2 wk of CPM followed by 50 wk of IAM |
| Delaney et al.52 | Clin Orthop Relat Res (1989) | Histology | 16 | Free periosteal autograft (intercondylar notch) | Range of motion NR; 3 wk of CPM |
| Kim et al.50 | J Bone Joint Surg Am (1991) | Histology | 80 | Abrasion of patella (40 subjects) and debridement of patella (40 subjects) | 40°–110° of flexion; 1 cycle/40 s; 2 wk of CPM plus either 2 wk or 10 wk of IAM |
| Zarnett et al.43 | J Bone Joint Surg Br (1991) | Histology | 46 | MCL reconstruction | 40°–110° of flexion; 1 cycle/45 s; 3 wk of CPM |
| Moran et al.48 | J Bone Joint Surg Br (1992) | Histology | 55 | Periosteal autograft (patella) | 40°–110° of flexion; 1 cycle/45 s; 24 h/d × 2 wk |
| Williams et al.45 | Clin Orthop Relat Res (1994) | Histology | 48 | Chymopapain-induced proteoglycan loss | 40°–110° of flexion; 1 cycle/45 s; 2 d of IAM followed by 7 or 19 d |
| Kim et al.49 | J Rheumatol (1995) | Histology | 22 | AIA | 40°–110° of flexion; 1 cycle/45 s; 24 h/d × 2 wk |
| Chang et al.44 | Biomaterials (2012) | Histology | 38 | Full-thickness OCD | 60°–130° of flexion; 1 cycle/20 s; 15 min/d × 7 d |
| Gershuni et al.56 | Sports Med (1988) | Nutrition | 20 | — | 130° of flexion to 40° of extension; 7 cycles/min; 10, 30, 60, and 120 min |
| Danzig et al.57 | J Orthop Res (1987) | Nutrition | 13 | — | 130° of flexion to 40° of extension; 7 cycles/min; 1 h of CPM |
| O’Driscoll et al.58 | Clin Orthop Relat Res (1983) | Trans-synovial transport | 25 | Hemarthrosis | 40°–110° of flexion; 7 d of CPM |
| Ferretti et al.53 | J Orthop Res (2005) | Biochemical | 20 | AIA | 40°–110° of flexion; 1 cycle/45 s; 24 or 48 h of CPM |
| Gassner et al.54 | Int J Oral Maxillofac Surg (2000) | Biochemical | In vitro chondrocyte | Inflammation | CTS |
| Xu et al.55 | J Immunol (2000) | Biochemical | In vitro chondrocyte | Inflammation | CTS |
AIA, antigen-induced arthritis; CTS, cyclic tensile strain; MCL, medial collateral ligament; NR, not reported; OCD, osteochondritis dissecans.