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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mini Rev Med Chem. 2016;16(5):358–369. doi: 10.2174/1389557515666151001154002

Fig. (3). Inhibition of Ras trafficking.

Fig. (3)

The prenylated Ras proteins require additional steps to achieve the membrane localization that is required for their activity. H-Ras, K-Ras4A, and N-Ras are reversibly palmitoylated. K-Ras4B requires interactions with chaperone proteins such as galectins or PDEδ. This figure is adapted and re-drawn from [156].