TABLE 3.
Predictive factors of overall survival among patients undergoing adrenal resection for ACC
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95 % CI | p Value | HR | 95 % CI | p Value | |
| Margin | ||||||
| R0 | Ref | Ref | ||||
| R1 | 2.65 | (1.49–4.73) | 0.001 | 2.22 | (1.03–4.77) | 0.04 |
| Age | 0.99 | (0.97–1.02) | 0.63 | 0.99 | (0.97–1.01) | 0.39 |
| Male gender | 0.86 | (0.49–1.53) | 0.61 | 0.85 | (0.43–1.67) | 0.64 |
| Race | ||||||
| White | Ref | Ref | ||||
| Black | 0.84 | (0.26–2.73) | 0.77 | 0.88 | (0.24–3.17) | 0.84 |
| Other | 0.85 | (0.38–1.90) | 0.69 | 0.42 | (0.15–1.17) | 0.1 |
| Laterality | ||||||
| Left | Ref | Ref | ||||
| Right | 1.36 | (0.79–2.35) | 0.27 | 1.45 | (0.79–2.65) | 0.23 |
| Functional tumor | 1.5 | (0.86–2.59) | 0.15 | 1.19 | (0.52–2.75) | 0.68 |
| Cortisol-secreting tumor | 1.72 | (0.86–3.48) | 0.13 | 1.19 | (0.42–3.37) | 0.74 |
| T stage | ||||||
| I/II | Ref | Ref | ||||
| III/IV | 1.74 | (0.96–3.16) | 0.07 | 1.30 | (0.61–2.77) | 0.50 |
| Capsular invasion | 1.82 | (0.91–3.62) | 0.09 | 1.39 | (0.55–3.49) | 0.48 |
| Tumor size | 1.05 | (0.99–1.10) | 0.09 | 1.04 | (0.98–1.11) | 0.2 |
| Postoperative chemotherapy | 0.92 | (0.34–2.52) | 0.87 | 0.61 | (0.15–2.42) | 0.48 |
| Postoperative mitotane | 1.21 | (0.64–2.28) | 0.55 | 0.91 | (0.42–2.00) | 0.82 |
| N stage | ||||||
| N0 | Ref | Ref | ||||
| N1 | 3.46 | (1.09–10.97) | 0.04 | 2.73 | (0.69–10.8) | 0.15 |
| Nx | 1.98 | (0.88–4.44) | 0.1 | 1.97 | (0.81–4.82) | 0.14 |