Precision medicine in advanced prostate cancer revolves around the ability to take a tumor sample, ideally metastatic tumor, sequence the tumor, and assign therapy to the patient. This involves biopsy of tumor tissue, DNA/RNA extraction, WES/WGS/Transcriptome sequencing, bioinformatics interpretation of results, and assignment of treatment based on therapeutic profile. This process may be repeated as needed when patients progress. WES, whole-exome sequencing; WGS, whole genome sequencing.