Table 3.
PCB body burdens from the NTP rat studies and human epidemiological studies.
| Study | PCB 118 | PCB 126 | PCB 153 | Sums of PCB congeners |
|---|---|---|---|---|
| Animal Studies | ||||
| NTP studies, measurements in ng/ml in blooda | 35.77 | 0.06391 | 57 | |
| NTP studies, per plasma equivalent, ng/mlb, | 47.57 | 0.085 | 76 | |
| Human studiesc | ||||
| Abdelouahab et al. (2008) | n/a | n/a | Maximum 2.87 Median 0.48 |
(Mono-ortho) Maximum 1.33 Median 0.130 (Non-coplanar) Maximum 2.87 Median 0.79 |
| Alvarez-Pedrerol et al. (2009)d (two cohorts) | Below LOD (0.071 ng/ml) | n/a | Median in two cohorts, 0.27 and 0.42 | |
| Bloom et al. (2003) | Maximum 0.642, mean 0.151 | n/a | Maximum 1.891 Mean 0.637 |
|
| Chevrier et al. (2008)d | Maximum 0.16, geometric mean 0.028 | n/a | Maximum 0.76, geometric mean 0.045 | (Mono-ortho) Maximum 0.97 Geometric mean 0.244 (All) Maximum 2.56 Geometric mean 0.52 |
| Dallaire et al. (2009a)d | Maximum 3.9 Geometric mean 0.18 |
n/a | Maximum 45.9 Geometric mean 1.4 |
(Mono-ortho) Maximum 6.8 Geometric mean 0.36 (All) Maximum 113 Geometric mean 5.0 |
| Dallaire et al. (2009b) | n/a | n/a | Maximum 6.12 Geometric mean 0.89 |
|
| Lopez-Espinosa et al. (2009) | n/a | n/a | n/a | (All) Maximum 14 Mean 1.3 |
| Maervoet et al. (2007) e | 95th percentile 0.27 Mean 0.12 |
n/a | 95th percentile 0.73 Mean 0.27 |
|
| Meeker et al. (2007) | 95th percentile 0.18 | n/a | 95th percentile 0.19 | 95th percentile 2.65 |
| Geometric mean 0.06 | Geometric mean 0.21 | Geometric mean 1.08 | ||
| Sala et al. (2001) | n/a | n/a | n/a | 6.7 in workers |
| Turyk et al. (2007) | Median in two cohorts, 0.048 and 0.059 | Median in two cohorts, 0.00012 and 0.00016 | Median in two cohorts, 0.20 and 0.23 | |
Listed values are for the highest PCB body burden measured for the lowest administered dose.
Concentrations in blood divided by blood:plasma partition coefficient of 0.75
Units are ng/ml or ng/g in plasma or serum. When data were reported for men and women separately, only data for women are listed.
Converted from a per-lipid basis using a value of 7.9 g lipid/liter of blood.
Converted from concentration in cord serum to concentration in maternal serum by dividing by 0.259 (see text).