Table 5.
Low-dose linear potency β from analysis of Crofton et al., 2005 data, relative potency (β for the given congener divided by β for the most potent congener, TCDD), and TEF (Van den Berg et al., 2006).
| Congenera | Structure | Low-dose Linear Potency β (95% confidence limit) (μg/kg/day)−1 | Low-dose Linear Potency (β) relative to TCDD | TEFb |
|---|---|---|---|---|
| PCB 28 | 2,4,4′-trichlorobiphenyl | 1.10 × 10−5 (9.17 × 10−6, 1.29 × 10−5) | 2.07 × 10−6 | 0 |
| PCB 52 | 2,5,2′,5′-tetrachlorobiphenyl | 1.70 × 10−5 (1.57 × 10−5, 1.82 × 10−5) | 3.20 × 10−6 | 0 |
| PCB 77 | 3,4,3′,4′-tetrachlorobiphenyl | 0.000695 (0.000636, 0.000753) | 0.000131 | 0.0001 |
| PCB 101 | 2,4,5,2′,5′-pentachlorobiphenyl | 9.70 × 10−5 (8.25 × 10−5, 0.000111) | 1.83 × 10−5 | 0 |
| PCB 105 | 2,3,4,3′,4′-pentachlorobiphenyl | 0.000919 (0.000786, 0.00105) | 0.000173 | 3 × 10−5 |
| *PCB 118 | 2,4,5,3′,4′-pentachlorobiphenyl | 0.000636 (0.000525, 0.000748) | 0.000120 | 3 × 10−5 |
| *PCB 126 | 3,4,5,3′,4′-pentachlorobiphenyl | 0.488 (0.433, 0.543) | 0.0919 | 0.1 |
| PCB 138 | 2,3,4,2′,4′,5′-hexachlorobiphenyl | 6.83 × 10−5 (6.03 × 10−5, 7.63 × 10−5) | 1.29 × 10−5 | 0 |
| *PCB 153 | 2,4,5,2′,4′,5′-hexachlorobiphenyl | 4.14 × 10−5 (4.01 × 10−5, 4.26 × 10−5) | 7.78 × 10−6 | 0 |
| PCB 156 | 2,3,4,5,3′,4′-hexachlorobiphenyl | 0.000695 (0.000634, 0.000756) | 0.000131 | 3 × 10−5 |
| PCB 169 | 3,4,5,3′,4′,5′-hexachlorobiphenyl | 0.00210 (0.00191, 0.00230) | 0.000396 | 0.03 |
| PCB 180 | 2,3,4,5,2′,4′,5′-heptachlorobiphenyl | 1.97 × 10−5 (1.57 × 10−5, 2.37 × 10−5) | 3.70 × 10−6 | 0 |
| TCDD | 2,3,7,8-tetrachlorodibenzo-p-dioxin | 5.31 (4.71, 5.91) | 1 | 1 |
| PCDD | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 0.640 (0.227, 1.05) | 0.120 | 0.03 |
| TCDF | 2,3,7,8-tetrachlorodibenzofuran | 0.194 (0.150, 0.237) | 0.0365 | 0.1 |
| 1-PCDF | 1,2,3,7,8-pentachlorodibenzofuran | 0.0506 (0.0446, 0.0566) | 0.00952 | 0.03 |
| 4-PCDF | 2,3,4,7,8-pentachlorodibenzofuran | 0.0177 (0.0138, 0.0216) | 0.00332 | 0.3 |
| OCDF | 1,2,3,4,6,7,8,9-octochlorodibenzofuran | 0.000168 (−3.33 × 10−5, 0.000370) | 3.17 × 10−5 | 0.0003 |
PCB congeners are in bold, and those in the NTP studies are marked with an asterisk (*).
A zero in the TEF column indicates a congener with no assigned TEF.