Table 2.
Brain Region | Atlas Coordinates† Millimeters |
p-value (uncorrected) | ||
---|---|---|---|---|
| ||||
X | Y | Z | ||
PSEN1 Mutation Carriers | ||||
Prefrontal Cortex | ||||
Left precentral gyrus | −36 | 8 | 31 | 0.001 |
Right superior frontal gyrus | 24 | 12 | 47 | 0.001 |
Parietal Cortex | ||||
Right angular gyrus | 27 | −61 | 49 | 0.0001 |
Right superior parietal gyrus | 24 | −70 | 49 | 0.002 |
Medial Temporal Lobes | ||||
Left medial temporal pole | −42 | 20 | −29 | 0.002 |
Left hippocampus | −21 | −40 | 1 | 0.003 |
Right hippocampus | 24 | −34 | 5 | 0.004 |
Right parahippocampal gyrus | 30 | −25 | −20 | 0.002 |
Right fusiform gyrus | 33 | −40 | −11 | 0.001 |
Left fusiform gyrus | −36 | −43 | −23 | 0.002 |
Non-Carriers | ||||
Parietal Cortex | ||||
Left inferior parietal lobule | −30 | −52 | 46 | 0.0001 |
Medial Temporal Lobes | ||||
Left parahippocampal gyrus | −30 | −28 | −19 | 0.0001 |
Right parahippocampal gyrus | 36 | −28 | −14 | 0.002 |
Left hippocampus | −24 | −34 | 5 | 0.002 |
Right hippocampus | 24 | −40 | 10 | 0.001 |
Left fusiform gyrus | −45 | −61 | −17 | 0.002 |
Left inferior temporal gyrus | −48 | 5 | −35 | 0.002 |