Table 2.
Evaluation of Consequential Instability
| Dry Ice | After shipment | |||||
|---|---|---|---|---|---|---|
| DMSO | 0.3 σp | Δ | ||||
| Method | HV | IV | LV | HV | IV | LV |
| Trypan Blue | 3.8 | 2.9 | 0.4 | 16.4* | 1.4 | 2.3* |
| CASY | 5.1 | 5.1 | 4.9 | 4.4 | 4.4 | 8.6* |
| Flow cytometry | 5.8 | 2.2 | 0.5 | 8.7* | 1.3 | 3.0* |
| DryIce | After shipment | |||||
|---|---|---|---|---|---|---|
| CryoStor | 0.3 σp | Δ | ||||
| Method | HV | IV | LV | HV | IV | LV |
| Trypan Blue | 3.9 | 3.5 | 0.8 | 1.2 | 3.0 | 4.9* |
| CASY | 5.1 | 5.8 | 5.1 | 1.0 | 1.4 | 0.4 |
| Flow cytometry | 6.2 | 3.0 | 0.6 | 0.2 | 4.2* | 0.0 |
σp, PT standard deviation, expressed as percent viability; Δ, viability percent difference between baseline and post-shipment conditions. *correspond to consequential instability.